Researchers 3D-print functional human brain tissue
研究人员 3D 打印出功能性人脑组织

Overview 概述

This article discusses the importance of research and simulation of human neural networks. We can learn that the human brain consists of specific types of neurons and glia that are connected together in precise ways to form networks. It is important to understand how human neural networks work if brain health and disease need to be studied. Animal models cannot fully reproduce the advanced information processing of the human brain because of differences in neurons, synaptic integration, astrocyte complexity, and neural networks between animals and humans. Therefore, a reliable model is needed for functional network assessment of human neural organization.

这篇文章讨论了关于人类神经网络的研究和模拟的重要性。我们可以得知，人脑由特定类型的神经元和神经胶质组成，并以精确的方式连接在一起形成网络。如果需要研究大脑的健康和疾病，了解人类神经网络的运作方式非常重要。动物模型无法完全重现人类大脑的高级信息处理，因为动物和人类之间神经元、突触集成、星形细胞复杂性和神经网络存在差异。因此，需要一个可靠的模型对人的神经组织进行功能网络评估。

Research Subject 研究主题

Scientists developed a 3D bioprinting platform for assembling human neuronal cell-type tissues. With this technique, printed neurons and glial cells can form functional connections within and between different tissues, mimicking the way human neural networks operate. Human neural tissues designed in this way can be used to study the wiring of neural networks, to simulate pathological processes, and as a platform for drug testing. This technique could be important for scientists to understand how the human brain works and may play an important role in neuroscience research.

科学家们开发了一种3D生物打印平台，用于组装人类神经细胞类型的组织。通过这种技术，印刷的神经元和胶质细胞可以在组织内部和不同组织之间形成功能连接，模拟人类神经网络的运作方式。这样设计的人类神经组织可以用于研究神经网络的布线、模拟病理过程以及作为药物测试的平台。这种技术对于科学家们来说，可以了解人类大脑的运作方式，并可能在神经科学研究中发挥重要作用。

Analysis of Research Ideas 研究思路分析

They have used 3D bioprinting to develop a platform to assemble 3D human neural tissues with definitions. By printing nerve cells and glial cells within and between tissue layers using a commercial bioprinter, functional connections are formed between neurons and astrocytes. The development of this technology could contribute to understanding how human neural networks function and mimic pathological processes as well as serve as a platform for drug testing. In addition, the article mentions the differences that exist between the design of human neural tissue and traditional animal models and emphasizes the importance of understanding human neural networks for brain health and disease. Finally, the article also describes a technology platform that utilizes extrusion bioprinting to horizontally print nerve cells and glial cells, resulting in defined 3D neural tissue.

他们利用3D生物打印技术开发了一个平台，可以组装具有定义的3D人类神经组织。通过在组织层内和组织层之间使用商业生物打印机打印神经细胞和胶质细胞，神经元和星形胶质细胞之间形成了功能连接。这种技术的发展可以有助于了解人类神经网络的运作方式，并模拟病理过程以及作为药物测试的平台。此外，文章还提到了人类神经组织的设计与传统动物模型存在的差异，并强调了了解人类神经网络对于大脑健康和疾病的重要性。最后，文章还介绍了利用挤压生物打印技术水平打印神经细胞和胶质细胞，从而形成定义的3D神经组织的技术平台。

Research Results and Significance 研究成果与意义

The 3D bioprinting platform developed in this study represents a significant advancement in the field of neuroscience and tissue engineering, as this platform is capable of precisely configuring human neural cells to form models of human neural networks with complex structures and functions. These models not only provide new tools for the study of the dynamics of neural networks but can also simulate disease processes and help develop and test new drugs.

这项研究开发的3D生物打印平台代表了神经科学和组织工程领域的一个重大进步，此平台能够精确配置人类神经细胞，形成具有复杂结构和功能的人类神经网络模型。这些模型不仅为神经网络的动态研究提供了新工具，还可以模拟疾病过程，帮助开发和测试新药物。

Implication 研究应用

These 3D neural tissues can be used to test the efficacy and safety of new drug candidates and accelerate the translation of drugs from the lab to the clinic. It can also be used to study the workings of the human brain, including the establishment, maintenance, and functional alterations of neural circuits, which are critical for revealing how the brain processes information. It can help understand how nerve cells grow and interact in a three-dimensional environment, potentially valuable for designing and improving neural tissue repair strategies and therapeutic interventions.

这些3D神经组织可以用来测试新药物候选物的效力和安全性，加速药物从实验室到临床的转化。还能研究人类大脑的运作，包括神经回路的建立、维持和功能性改变，对于揭示大脑如何处理信息至关重要。并且可以帮助理解神经细胞如何在三维环境中生长和相互作用，对于设计和改善神经组织修复策略和治疗性干预具有潜在价值。

Overall, this study provides us with a powerful tool to replicate and study the complexity of the human brain, potentially revolutionizing our treatment of neurological disorders, improving our understanding of cognitive function and brain disorders, and leading to a variety of innovative therapeutic strategies in the future.

总的来说，这项研究为我们提供了一个复制和研究人脑复杂性的强大工具，可能会革新我们对神经系统疾病的治疗，增进我们对于认知功能和大脑疾病的理解，并在未来形成各种创新的治疗策略。