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Monkeypox mutations cause virus to spread rapidly, evade drugs and vaccines
猴痘突变导致病毒迅速传播,逃脱药物和疫苗

Scientists study the different mutant strains of the monkeypox virus temporally to see what contributes to its continued infectiousness. This could be applied in improving or designing new drugs for treatment.
科学家们从时间角度研究猴痘病毒的不同变异株,探索是什么导致了它的持续传染性。这可以应用于改进或设计新的治疗药物。

Miaomiao Ding

Overview 概述


Scientists study the different mutant strains of the monkeypox virus temporally to see what contributes to its continued infectiousness. This could be applied in improving or designing new drugs for treatment.


科学家们从时间角度研究猴痘病毒的不同变异株,探索是什么导致了它的持续传染性。这可以应用于改进或设计新的治疗药物。


Research Subject 研究主题


The monkeypox virus first started to spread in 1965. It’s a virus similar to the vaccinia virus that is used in smallpox vaccinations.  It causes a painful rash, enlarged lymph nodes and fever that typically recedes in a few weeks.


猴痘病毒于1965年首次开始传播。这是一种与天花疫苗接种中使用的牛痘病毒相似的病毒。它会导致令人疼痛的皮疹、淋巴结肿大和发烧,通常几周后症状就会消退。


Analysis of Research Ideas 研究思路分析


First, the researchers were able to create an accurate model of the monkeypox virus thanks to its similarity with the vaccinia virus. The 3D model of virus proteins allows comparison of specific mutations. Then, the researchers specifically looked at the genes responsible for replicating the virus. They narrowed down to five proteins: DNA polymerase, DNA helicase, bridging protein A22R, DNA glycosylase and G9R. They identified changes to DNA binding in the protein molecules, which are also used by drugs and antibodies to bind.


首先,由于猴痘病毒与牛痘病毒相似,研究人员能够创建猴痘病毒的准确模型。病毒蛋白的3D模型允许对特定突变进行比较。然后,研究人员专门研究了负责复制病毒的基因。他们将范围缩小到五种蛋白质:DNA聚合酶、DNA解旋酶、桥接蛋白A22R、DNA糖基化酶和G9R。他们确定了蛋白质分子中DNA结合的变化,药物和抗体正是利用了这种结合。


病毒突变 Viral Mutation


The researchers hypothesized the reduced efficacy of CDC-approved virus drugs. One hypothesis is that the virus may be hijacking body cells and increasing infectiousness.


研究人员对美国疾病控制与预防中心批准的病毒药物的疗效降低做出假设。一种假设是,这种病毒可能正在劫持人体细胞并增加传染性。


Another hypothesis is the monkeypox virus was originally used in HIV and herpes virus treatment.  This means that patients suffering from the two diseases could be infected unknowingly by monkeypox and provide the site for mutations.


另一种假说是猴痘病毒最初用于治疗艾滋病毒和疱疹病毒。这意味着治疗这两种疾病的患者可能会在未知的情况下被猴痘感染,并提供突变位点。


研究意义 Research Significance


The results of this study demonstrate the importance of the evolution of the monkeypox virus. The team has successfully modelled the monkeypox virus and analyzed ways that its treatment is developed and improved. It plays an important role in designing more effective treatment options.


这项研究的结果证明了猴痘病毒进化的重要性。该团队成功地对猴痘病毒进行了建模,并分析了开发和改进其治疗方法的方法。它在设计更有效的治疗方案方面发挥着重要作用。

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