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The new compound inhibits influenza virus replication

A compound is formed by connecting two or more substances through chemical bonds of a certain molecular weight. Chemical substances are often referred to as pure substances or pure substances. A plant is a substance with certain properties and characteristics. A chemical substance can be a simple substance or a chemical substance.


Examples of compounds are:

Water (H2O)

Common Salt (NaCI)

Soap (C17H35COO)

Baking Soda (NaHCO3)

Sugar (C12H22O11)



Influenza is a viral infection that affects your respiratory system; nose, throat and lungs. Influenza is often called influenza, but it is different from the stomach flu virus which causes diarrhea and vomiting. Most people can cope with the flu on their own. However, complications can sometimes be fatal. Of course, the best protection against the flu is an annual flu shot, but even with a flu shot, it's sometimes unavoidable.



Viruses use cellular molecules to reproduce within a host. Researchers at the University of Bonn, in collaboration with Japanese researchers, hope it can be used to treat influenza. A team led by Professor Hiroki Kato of the Institute of Cardiovascular Immunology at the University of Bonn Hospital in Germany has discovered a new compound that can inhibit the methyltransferase Mtr1 in humans. According to data, this thing can Restrict the replication of the influenza virus in the body. The idea was made possible in a study using mice.


Viruses need access to the host's cells to replicate. They introduce their genetic information in the form of DNA or RNA. These are used to generate new viruses. Cells use a marker system to distinguish their nucleic acids from foreign ones. Self-nucleic acids are identified as harmless, and foreign nucleic acids are identified as threatening. This allows the immune system to face danger more efficiently.


Small molecules are attached to the ends of the RNA. This way of marking does not trigger an immune response. If the cap RNA is missing from the cell, it is recognized and the immune system is alerted. To prevent things like this from happening, the flu virus has invented a special mechanism. They steal the molecular cap from cellular RNA molecules and transfer it to their RNA. This process is called cap-snatching.


The cap structure of cellular mRNA comes from MTr1. The MTr1 enzyme provides the cap structure to cellular mRNA, and this action acts as a "nucleic acid marker" of the cell. A team led by Prof. Hiroki Kato from the Institute of Cardiovascular Immunology at the University of Bonn in Germany has now been able to show how much influenza viruses depend on the function of the MTr1 enzyme. Although SARS-CoV-2 and other viruses can automatically cap RNA molecules, viruses prefer to steal existing caps. If MTr1 is disrupted, there is no cap transfer to viral RNA. So the activity of MTr1 is a very important factor, which determines the replication of the influenza virus in cells.



Researchers at universities in Germany and Japan hope to exploit the relationship between MTr1 and influenza viruses to treat influenza viruses. For this project, the researchers plan to find an inhibitor that would inhibit MTr1. They investigated how substances in infected tissue affect the rate and number of viral particles produced. They tested it in a mouse model and human lung tissue preparations. Among thousands of candidates, the researchers identified a molecule that inhibits MTr1 in human lung explants and MTr1 in mice, thereby inhibiting influenza virus replication.

Trifluoromethyl tuberculin (TFMT), is a compound that inhibits influenza viruses (for example: Covid-19). TFMT inhibits the function of the body's enzyme MTr1, inhibiting a process called cap-snatching caused by the influenza virus that allows the virus to replicate as a "green channel."


In addition to the University of Bonn and the University Hospital Bonn, the study involved Hokkaido University (Japan), the National Institute of Infectious Diseases Tokyo (Japan), the National Institute of Advanced Industrial Science and Technology Tokyo (Japan), the University of Tsukuba (Japan), Aarhus University (Denmark), Academia Sinica Taipei (Taiwan) as well as the Universities of Münster, Marburg and Freiburg, the Technical University of Munich and the German Center for Infection Research (DZIF). The work was supported by the German Research Foundation (DFG) and the Japan Society for the Promotion of Science (JSPS).


Soloxolone methyl is another thing that can suppress the flu virus. Inhibits M2 ion channel activity by preventing migration of H+ ions into the interior of virus particles in the endosome, a process required for uncoating to occur.




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