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Alzheimer's Disease

Nina

Alzheimer’s disease is the most common type of dementia which is causedby the formation of unusual deposits of protein in the brain called Plaquesand Tangles. Alzheimer’s disease makes up 60-80% of dementia cases.Recently researchers have been able to detect toxic small proteins in theblood of individuals with Alzheimer’s disease.

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Alzheimer's disease is classified as a severe symptom. Scientists haveclassified it as disorientation, mood and behaviour changes; confusion aboutevents that have happened; more serious of memory loss as well as difficultyspeaking and walking. Signs of dementia may be easy for family members orfriends to recognize.

For healthy people, all movements, thoughts, memories and feelings arethe consequences of the signals passing through billions of nerve cells, alsorecognized as the Neurons. Neurons steadily communicate with each other.The nerve cells have special jobs like thinking, learning and memorising.Other cells like Astrocyte and Microglia help keep neurons healthy. For aperson who has Alzheimer's disease, toxic changes in the brain will destroythe healthy balance. This process includes two proteins which are calledBeta- amyloid and Tau eventually become toxic to the brain . Abnormal Tauforms tangles inside the neurons and then beta- amyloid clusters into plaques.


Tau and Beta- amyloid are not the only reason for the cause of Alzheimerdisease. Another cause is that the vascular system may not be able to giveabundant blood and nutrients to the brain, which may cause the brain lacks ofglucose that can power its activity. Eventually neurons lose their capacity tocorrespond . As the neurons die, the hippocampus which is a significant partof learning and memory. People start to experience memory loss, when moreneurons die the people starts to losing their ability to think.


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Recent scientists at the University of Washington have expanded alaboratory test that can measure the levels of amyloid beta oligomers in bloodsamples. SOBA detected oligomers in the blood of 22 individuals; most ofthose individuals are diagnosed years with Alzhimer’s disease. SOBA uses asynthetic alpha sheet that can bind to oligomers in samples from individualsblood. Then they use standard methods to confirm oligomers attached to thetest surface are made up of amyloid beta proteins . At the time when bloodsamples were taken, it was recorded that there were no signs of cognitiveimpairment. Some control group records show there is later developedcognitive impairment. Blood samples from the other control group whostayed unimpaired lacked toxic oligomers. Scientists believed oligomerstriggers the development of Alzhimer’s disease.


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Alzgeimer’s disease can be prevented by doing physical exercise and diet.Physical exercise can lower the risk of Alzhimer’s annd vasuclar dementia.Exercise benefits brain cells by increasing blood and oxygen flow in thebrain. Heart-healthy eating may help protect the brain. Heart-healthy eatingincludes limiting the amount of sugar and sautrated facts and make sure to eatvegetables and fruits. Secondly maintianing strong social ocnnections mightlower the risk of Alzheimer’s .

Alzheimer's disease is a progressive disorder that causes the brain toshrink and brain cells to die. Alzhemier’s disease is the most common causeof dementia . Scientists was able to use toxic small proteins in the blood ofindivuals detected oligomers from Alzhemier’s disease. Scientists believedoligomers triggers the development of Alzhimer’s disease.



Reference

“Can Alzheimer's Disease Be Prevented?” Alzheimer's Disease and Dementia,https://www.alz.org/alzheimers-dementia/research_progress/prevention.

https://www.sciencedaily.com/releases/2022/12/221205153722.htm.

https://www.youtube.com/watch?v=v5gdH_Hydes

https://www.youtube.com/watch?v=0GXv3mHs9AU&t=162s



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